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 Previous Article

J Virol. 1992 April; 66(4): 2594-2599

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells.

J Robbins, B J Blondel, D Gallahan and R Callahan

Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland 20892.

ABSTRACT

Expression of a 2.3-kb RNA species is induced in mammary tumors as a consequence of insertional mutagenesis at the int-3 locus by the mouse mammary tumor virus. The nucleotide sequence and biological activity of this mammary tumor-specific int-3 RNA species were determined. It contains an open reading frame which encodes a 57-kDa protein. The translated protein possesses six nearly contiguous 32-amino-acid repeats which are related to a similar motif in the Saccharomyces cerevisiae cdc-10-encoded cell cycle protein. In addition, the int-3 cdc-10 repeats are bounded by the PEST amino acid sequence motif which is commonly found in proteins having a rapid turnover and may represent sites for phosphorylation. The int-3 cdc-10 repeat sequences are 50% identical to a portion of the intracellular domain of the neurogenic Drosophila notch gene product. Activation of expression of a recombinant int-3 genomic DNA fragment encoding the 2.3-kb RNA species in HC11 mouse mammary epithelial cells in vitro induces anchorage-independent growth in soft agar.

J Virol. 1992 April; 66(4): 2594-2599




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