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J Virol. 1992 March; 66(3): 1804-1808

Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.

M Carbone, J Hauser, M P Carty, K Rundell, K Dixon and A S Levine

Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.

ABSTRACT

We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.

J Virol. 1992 March; 66(3): 1804-1808






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Copyright © 1992 by the American Society for Microbiology. All rights reserved.