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J Virol. 1991 January; 65(1): 473-478

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells.

C L Halbert, G W Demers and D A Galloway

Fred Hutchinson Cancer Research Center, Seattle, Washington 98104-2092.

ABSTRACT

The contribution of the E6 and E7 open reading frames of human papillomavirus type 6b (HPV6b) and HPV16 to immortalization of human keratinocytes was evaluated by using amphotropic recombinant retroviruses. The HPV16 E7 gene could immortalize primary human keratinocytes without the cooperation of the viral E6 gene; however, E6 was able to contribute significantly to the efficiency of the E7 immortalizing function. Infection of HFE cells with retroviruses carrying the 16E6, 6bE6, or 6bE6E7 open reading frame did not result in immortalization.

J Virol. 1991 January; 65(1): 473-478




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  • Escalante-Alcalde, D., Recillas-Targa, F., Valencia, C., Santa-Olalla, J., Chávez, P., Marroquín, A., Gutiérrez-X, L., Gariglio, P., Covarrubias, L. (2000). Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen. Cell Growth Differ. 11: 527-539 [Abstract] [Full Text]  
  • Diggle, C. P., Pitt, E., Roberts, P., Trejdosiewicz, L. K., Southgate, J. (2000). N-3 and n-6 polyunsaturated fatty acids induce cytostasis in human urothelial cells independent of p53 gene function. J. Lipid Res. 41: 1509-1515 [Abstract] [Full Text]  
  • Nees, M., Geoghegan, J. M., Munson, P., Prabhu, V., Liu, Y., Androphy, E., Woodworth, C. D. (2000). Human Papillomavirus Type 16 E6 and E7 Proteins Inhibit Differentiation-dependent Expression of Transforming Growth Factor-{beta}2 in Cervical Keratinocytes. Cancer Res. 60: 4289-4298 [Abstract] [Full Text]  
  • Woodworth, C. D., Gaiotti, D., Michael, E., Hansen, L., Nees, M. (2000). Targeted Disruption of the Epidermal Growth Factor Receptor Inhibits Development of Papillomas and Carcinomas from Human Papillomavirus-immortalized Keratinocytes. Cancer Res. 60: 4397-4402 [Abstract] [Full Text]  
  • Rai, S. K., DeMartini, J. C., Miller, A. D. (2000). Retrovirus Vectors Bearing Jaagsiekte Sheep Retrovirus Env Transduce Human Cells by Using a New Receptor Localized to Chromosome 3p21.3. J. Virol. 74: 4698-4704 [Abstract] [Full Text]  
  • Crish, J. F., Bone, F., Balasubramanian, S., Zaim, T. M., Wagner, T., Yun, J., Rorke, E. A., Eckert, R. L. (2000). Suprabasal expression of the human papillomavirus type 16 oncoproteins in mouse epidermis alters expression of cell cycle regulatory proteins. Carcinogenesis 21: 1031-1037 [Abstract] [Full Text]  
  • Francis, D. A., Schmid, S. I., Howley, P. M. (2000). Repression of the Integrated Papillomavirus E6/E7 Promoter Is Required for Growth Suppression of Cervical Cancer Cells. J. Virol. 74: 2679-2686 [Abstract] [Full Text]  
  • Griffith, M., Osborne, R., Munger, R., Xiong, X., Doillon, C. J., Laycock, N. L., Hakim, M., Song, Y., Watsky, M. A. (1999). Functional Human Corneal Equivalents Constructed from Cell Lines. Science 286: 2169-2172 [Abstract] [Full Text]  
  • Spancake, K. M., Anderson, C. B., Weaver, V. M., Matsunami, N., Bissell, M. J., White, R. L. (1999). E7-transduced Human Breast Epithelial Cells Show Partial Differentiation in Three-dimensional Culture. Cancer Res. 59: 6042-6045 [Abstract] [Full Text]  
  • Johnson, G. A., Burghardt, R. C., Newton, G. R., Bazer, F. W., Spencer, T. E. (1999). Development and Characterization of Immortalized Ovine Endometrial Cell Lines. Biol. Reprod. 61: 1324-1330 [Abstract] [Full Text]  
  • Shapiro, G. I., Koestner, D. A., Matranga, C. B., Rollins, B. J. (1999). Flavopiridol Induces Cell Cycle Arrest and p53-independent Apoptosis in Non-Small Cell Lung Cancer Cell Lines. Clin. Cancer Res. 5: 2925-2938 [Abstract] [Full Text]  
  • Passalaris, T. M., Benanti, J. A., Gewin, L., Kiyono, T., Galloway, D. A. (1999). The G2 Checkpoint Is Maintained by Redundant Pathways. Mol. Cell. Biol. 19: 5872-5881 [Abstract] [Full Text]  
  • Alani, R. M., Hasskarl, J., Grace, M., Hernandez, M.-C., Israel, M. A., Munger, K. (1999). Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1. Proc. Natl. Acad. Sci. USA 96: 9637-9641 [Abstract] [Full Text]  
  • Moses, A. V., Fish, K. N., Ruhl, R., Smith, P. P., Strussenberg, J. G., Zhu, L., Chandran, B., Nelson, J. A. (1999). Long-Term Infection and Transformation of Dermal Microvascular Endothelial Cells by Human Herpesvirus 8. J. Virol. 73: 6892-6902 [Abstract] [Full Text]  
  • Wong, D. J., Foster, S. A., Galloway, D. A., Reid, B. J. (1999). Progressive Region-Specific De Novo Methylation of the p16 CpG Island in Primary Human Mammary Epithelial Cell Strains during Escape from M0 Growth Arrest. Mol. Cell. Biol. 19: 5642-5651 [Abstract] [Full Text]  
  • Fournier, M. V., Guimaraes, F. C., Paschoal, M. E. M., Ronco, L. V., Carvalho, M. d. G. C., Pardee, A. B. (1999). Identification of a Gene Encoding a Human Oxysterol-binding Protein-Homologue: A Potential General Molecular Marker for Blood Dissemination of Solid Tumors. Cancer Res. 59: 3748-3753 [Abstract] [Full Text]  
  • Prichard, M. N., Gao, N., Jairath, S., Mulamba, G., Krosky, P., Coen, D. M., Parker, B. O., Pari, G. S. (1999). A Recombinant Human Cytomegalovirus with a Large Deletion in UL97 Has a Severe Replication Deficiency. J. Virol. 73: 5663-5670 [Abstract] [Full Text]  
  • Song, S., Pitot, H. C., Lambert, P. F. (1999). The Human Papillomavirus Type 16 E6 Gene Alone Is Sufficient To Induce Carcinomas in Transgenic Animals. J. Virol. 73: 5887-5893 [Abstract] [Full Text]  
  • Jarrard, D. F., Sarkar, S., Shi, Y., Yeager, T. R., Magrane, G., Kinoshita, H., Nassif, N., Meisner, L., Newton, M. A., Waldman, F. M., Reznikoff, C. A. (1999). p16/pRb Pathway Alterations Are Required for Bypassing Senescence in Human Prostate Epithelial Cells. Cancer Res. 59: 2957-2964 [Abstract] [Full Text]  
  • Bond, J. A., Haughton, M. F., Rowson, J. M., Smith, P. J., Gire, V., Wynford-Thomas, D., Wyllie, F. S. (1999). Control of Replicative Life Span in Human Cells: Barriers to Clonal Expansion Intermediate Between M1 Senescence and M2 Crisis. Mol. Cell. Biol. 19: 3103-3114 [Abstract] [Full Text]  
  • Ronco, L. V., Karpova, A. Y., Vidal, M., Howley, P. M. (1998). Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. Genes Dev. 12: 2061-2072 [Abstract] [Full Text]  
  • Foster, S. A., Wong, D. J., Barrett, M. T., Galloway, D. A. (1998). Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation. Mol. Cell. Biol. 18: 1793-1801 [Abstract] [Full Text]  
  • Martin, L. G., Demers, G. W., Galloway, D. A. (1998). Disruption of the G1/S Transition in Human Papillomavirus Type 16 E7-Expressing Human Cells Is Associated with Altered Regulation of Cyclin E. J. Virol. 72: 975-985 [Abstract] [Full Text]  
  • Thomas, J. T., Laimins, L. A. (1998). Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint. J. Virol. 72: 1131-1137 [Abstract] [Full Text]  
  • Shih, I, Wang, T, Wu, T, Kurman, R., Gearhart, J. (1998). Expression of Mel-CAM in implantation site intermediate trophoblastic cell line, IST-1, limits its migration on uterine smooth muscle cells. J. Cell Sci. 111: 2655-2664 [Abstract]  
  • Greaves, R. F., Mocarski, E. S. (1998). Defective Growth Correlates with Reduced Accumulation of a Viral DNA Replication Protein after Low-Multiplicity Infection by a Human Cytomegalovirus ie1 Mutant. J. Virol. 72: 366-379 [Abstract] [Full Text]  
  • Berezutskaya, E., Bagchi, S. (1997). The Human Papillomavirus E7 Oncoprotein Functionally Interacts with the S4 Subunit of the 26 S Proteasome. J. Biol. Chem. 272: 30135-30140 [Abstract] [Full Text]  
  • Kiyono, T., Hiraiwa, A., Fujita, M., Hayashi, Y., Akiyama, T., Ishibashi, M. (1997). Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc. Natl. Acad. Sci. USA 94: 11612-11616 [Abstract] [Full Text]  
  • Jones, D. L., Alani, R. M., Munger, K. (1997). The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 11: 2101-2111 [Abstract] [Full Text]  
  • Stoppler, H., Hartmann, D.-P., Sherman, L., Schlegel, R. (1997). The Human Papillomavirus Type 16 E6 and E7 Oncoproteins Dissociate Cellular Telomerase Activity from the Maintenance of Telomere Length. J. Biol. Chem. 272: 13332-13337 [Abstract] [Full Text]  
  • Reznikoff, C A, Belair, C, Savelieva, E, Zhai, Y, Pfeifer, K, Yeager, T, Thompson, K J, DeVries, S, Bindley, C, Newton, M A (1994). Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells.. Genes Dev. 8: 2227-2240 [Abstract]  
  • White, A E, Livanos, E M, Tlsty, T D (1994). Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.. Genes Dev. 8: 666-677 [Abstract]  
  • Castro-Munozledo, F (1994). Development of a spontaneous permanent cell line of rabbit corneal epithelial cells that undergoes sequential stages of differentiation in cell culture. J. Cell Sci. 107: 2343-2351 [Abstract]  
  • Galloway, D.A., Demers, G.W., Foster, S.A., Halbert, C.L., Russell, K. (1994). Cell Cycle Checkpoint Control Is Bypassed by Human Papillomavirus Oncogenes. Cold Spring Harb Symp Quant Biol 59: 297-306 [Abstract]  
  • zur Hausen, H., Rosl, F. (1994). Pathogenesis of Cancer of the Cervix. Cold Spring Harb Symp Quant Biol 59: 623-628 [Abstract]  
  • Dollard, S C, Wilson, J L, Demeter, L M, Bonnez, W, Reichman, R C, Broker, T R, Chow, L T (1992). Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures. OFF.. Genes Dev. 6: 1131-1142 [Abstract]  
  • Howley, P.M., Scheffner, M., Huibregtse, J., Munger, K. (1991). Oncoproteins Encoded by the Cancer-associated Human Papillomaviruses Target the Products of the Retinoblastoma and p53 Tumor Suppressor Genes. Cold Spring Harb Symp Quant Biol 56: 149-155 [Abstract]  
  • Duensing, S., Lee, L. Y., Duensing, A., Basile, J., Piboonniyom, S.-o., Gonzalez, S., Crum, C. P., Munger, K. (2000). The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc. Natl. Acad. Sci. USA 97: 10002-10007 [Abstract] [Full Text]  


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