This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brüssow, H Articles by Sidoti, J Search for Related Content PubMed PubMed Citation Articles by Brüssow, H Articles by Sidoti, J

Polypeptide specificity of antiviral serum antibodies in children naturally infected with human rotavirus.

Nestlé Research Centre, Lausanne, Switzerland.

ABSTRACT

Reassortants between serotype 3 SA11 and serotype 6 NCDV rotaviruses were used to determine the relative amounts of serum-neutralizing antibody to VP4 and VP7 of serotype 3 SA11 rotavirus in children after natural rotavirus exposure. Sera from Ecuadorian children of a population-based study and sera from children of a hospital-based study in Germany (excluding diarrhea patients) demonstrated high titers of VP7-specific but only low titers of VP4-specific antibodies. In contrast, paired sera from German children hospitalized with a symptomatic primary rotavirus gastroenteritis demonstrated a titer increase to VP4 more frequently than to VP7 protein by neutralization test and immunoblotting. For these rotavirus patients, we provided, previously, direct evidence for the development of cross-neutralizing antibodies.

This article has been cited by other articles:

• Delorme, C., Brüssow, H., Sidoti, J., Roche, N., Karlsson, K.-A., Neeser, J.-R., Teneberg, S. (2001). Glycosphingolipid Binding Specificities of Rotavirus: Identification of a Sialic Acid-Binding Epitope. J. Virol. 75: 2276-2287 [Abstract] [Full Text]