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J Virol. 1990 March; 64(3): 1353-1356

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.

ABSTRACT

Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.

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