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J Virol. 1990 March; 64(3): 1207-1216

Isolation and partial characterization of an unusual human immunodeficiency retrovirus from two persons of west-central African origin.

R De Leys, B Vanderborght, M Vanden Haesevelde, L Heyndrickx, A van Geel, C Wauters, R Bernaerts, E Saman, P Nijs and B Willems

Innogenetics N.V., Antwerp, Belgium.

ABSTRACT

An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgium. Although the virus shared a number of the same biological and morphological properties as human immunodeficiency retrovirus type 1 (HIV-1) and HIV-2, significant antigenic differences could be demonstrated. Several of the viral proteins also differed in molecular weight from the corresponding HIV-1 and HIV-2 proteins. Partial chemical cleavage of the most highly conserved viral proteins resulted in patterns which differed from those of HIV-1 and HIV-2. Furthermore, nucleic acid hybridization experiments were capable of discriminating between the virus types. Sequence analysis of the viral U3 region revealed a unique enhancer organization not found in other immunodeficiency viruses. The data indicated that the new isolate is more closely related to HIV-1 than to HIV-2 but clearly differs in a number of important respects.

J Virol. 1990 March; 64(3): 1207-1216




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