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J Virol. 1990 February; 64(2): 639-641

Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor.

S T Donta and J D Shanley

Department of Medicine, University of Connecticut School of Medicine, Farmington 06032.

ABSTRACT

Reovirus type 3 interfered with the binding of beta-adrenergic antagonist ligands to receptors on Y1 adrenal, C6 glioma, and mouse L cells. This inhibition of beta-adrenergic binding was dose related. Reovirus did not interfere with dopaminergic binding or isoproterenol-induced activation of adenylate cyclase. In addition, reovirus infected Y1 cells, which bind beta-adrenergic antagonist ligands but lack agonist-induced activity. These results suggest that reovirus infection is initiated by binding to antagonist (nonfunctional) domains of the adrenergic receptor complex.

J Virol. 1990 February; 64(2): 639-641




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