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J Virol. 1990 November; 64(11): 5678-5681

Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11.

Department of Pathology, Milton S. Hershey Medical Center, Pennsylvania 17033.

ABSTRACT

Monoclonal antibodies recognizing human papillomavirus type 11 (HPV-11) were prepared from BALB/c mice immunized with intact HPV-11 virions obtained from morphologically transformed human foreskin xenografts grown subrenally in athymic mice. Four of five monoclonal antibodies that were reactive by enzyme-linked immunosorbent assay only to intact virions neutralized HPV-11 infectivity in the athymic mouse xenograft system.

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