This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Belsham, G J Articles by Brangwyn, J K Search for Related Content PubMed PubMed Citation Articles by Belsham, G J Articles by Brangwyn, J K

 Previous Article  |  Next Article 

J Virol. 1990 November; 64(11): 5389-5395

A region of the 5' noncoding region of foot-and-mouth disease virus RNA directs efficient internal initiation of protein synthesis within cells: involvement with the role of L protease in translational control.

AFRC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, United Kingdom.

ABSTRACT

Plasmids encoding bicistronic mRNAs have been constructed and used to identify a region from the 5' noncoding region of foot-and-mouth disease virus (FMDV) which directs efficient internal initiation of protein synthesis within cells. The loss of about 30 nucleotides (nt) from the 5' terminus or about 50 nt from the 3' terminus of the 435-nt region completely abolished the activity of this region. The expression of the FMDV L protease severely inhibited the expression of other genes unless they were preceded by this element. The regulation of protein synthesis mediated by FMDV is discussed.

This article has been cited by other articles:

• de los Santos, T., Diaz-San Segundo, F., Grubman, M. J. (2007). Degradation of Nuclear Factor Kappa B during Foot-and-Mouth Disease Virus Infection. J. Virol. 81: 12803-12815 [Abstract] [Full Text]  
• Lu, J., Zhang, J., Wang, X., Jiang, H., Liu, C., Hu, Y. (2006). In vitro and in vivo identification of structural and sequence elements in the 5' untranslated region of Ectropis obliqua picorna-like virus required for internal initiation. J. Gen. Virol. 87: 3667-3677 [Abstract] [Full Text]  
• Ellingham, M., Bunka, D. H.J., Rowlands, D. J., Stonehouse, N. J. (2006). Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus. RNA 12: 1970-1979 [Abstract] [Full Text]  
• de los Santos, T., de Avila Botton, S., Weiblen, R., Grubman, M. J. (2006). The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Beta Interferon mRNA and Blocks the Host Innate Immune Response. J. Virol. 80: 1906-1914 [Abstract] [Full Text]  
• Grubman, M. J., Baxt, B. (2004). Foot-and-Mouth Disease. Clin. Microbiol. Rev. 17: 465-493 [Abstract] [Full Text]  
• Clark, A. T., Robertson, M. E. M., Conn, G. L., Belsham, G. J. (2003). Conserved Nucleotides within the J Domain of the Encephalomyocarditis Virus Internal Ribosome Entry Site Are Required for Activity and for Interaction with eIF4G. J. Virol. 77: 12441-12449 [Abstract] [Full Text]  
• Rosas, M. F., Martinez-Salas, E., Sobrino, F. (2003). Stable expression of antisense RNAs targeted to the 5' non-coding region confers heterotypic inhibition to foot-and-mouth disease virus infection. J. Gen. Virol. 84: 393-402 [Abstract] [Full Text]  
• van Munster, M., Dullemans, A. M., Verbeek, M., van den Heuvel, J. F. J. M., Clerivet, A., van der Wilk, F. (2002). Sequence analysis and genomic organization of Aphid lethal paralysis virus: a new member of the family Dicistroviridae. J. Gen. Virol. 83: 3131-3138 [Abstract] [Full Text]  
• Lopez de Quinto, S., Saiz, M., de la Morena, D., Sobrino, F., Martinez-Salas, E. (2002). IRES-driven translation is stimulated separately by the FMDV 3'-NCR and poly(A) sequences. Nucleic Acids Res 30: 4398-4405 [Abstract] [Full Text]  
• Mason, P. W., Bezborodova, S. V., Henry, T. M. (2002). Identification and Characterization of a cis-Acting Replication Element (cre) Adjacent to the Internal Ribosome Entry Site of Foot-and-Mouth Disease Virus. J. Virol. 76: 9686-9694 [Abstract] [Full Text]  
• Woolaway, K. E., Lazaridis, K., Belsham, G. J., Carter, M. J., Roberts, L. O. (2001). The 5' Untranslated Region of Rhopalosiphum padi Virus Contains an Internal Ribosome Entry Site Which Functions Efficiently in Mammalian, Plant, and Insect Translation Systems. J. Virol. 75: 10244-10249 [Abstract] [Full Text]  
• Hinton, T. M., Crabb, B. S. (2001). The novel picornavirus Equine rhinitis B virus contains a strong type II internal ribosomal entry site which functions similarly to that of Encephalomyocarditis virus. J. Gen. Virol. 82: 2257-2269 [Abstract] [Full Text]  
• Low, W., Harries, M., Ye, H., Du, M.-Q., Boshoff, C., Collins, M. (2001). Internal Ribosome Entry Site Regulates Translation of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein. J. Virol. 75: 2938-2945 [Abstract] [Full Text]  
• Buck, C. B., Shen, X., Egan, M. A., Pierson, T. C., Walker, C. M., Siliciano, R. F. (2001). The Human Immunodeficiency Virus Type 1 gag Gene Encodes an Internal Ribosome Entry Site. J. Virol. 75: 181-191 [Abstract] [Full Text]  
• Hinton, T. M., Li, F., Crabb, B. S. (2000). Internal Ribosomal Entry Site-Mediated Translation Initiation in Equine Rhinitis A Virus: Similarities to and Differences from That of Foot-and-Mouth Disease Virus. J. Virol. 74: 11708-11716 [Abstract] [Full Text]  
• Nateri, A. S., Hughes, P. J., Stanway, G. (2000). In Vivo and In Vitro Identification of Structural and Sequence Elements of the Human Parechovirus 5' Untranslated Region Required for Internal Initiation. J. Virol. 74: 6269-6277 [Abstract] [Full Text]  
• Belsham, G. J., McInerney, G. M., Ross-Smith, N. (2000). Foot-and-Mouth Disease Virus 3C Protease Induces Cleavage of Translation Initiation Factors eIF4A and eIF4G within Infected Cells. J. Virol. 74: 272-280 [Abstract] [Full Text]  
• Mulder, J., Robertson, M. E. M., Seamons, R. A., Belsham, G. J. (1998). Vaccinia Virus Protein Synthesis Has a Low Requirement for the Intact Translation Initiation Factor eIF4F, the Cap-Binding Complex, within Infected Cells. J. Virol. 72: 8813-8819 [Abstract] [Full Text]  
• Poulin, F., Gingras, A.-C., Olsen, H., Chevalier, S., Sonenberg, N. (1998). 4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family. J. Biol. Chem. 273: 14002-14007 [Abstract] [Full Text]  
• Gan, W., Rhoads, R. E. (1996). Internal Initiation of Translation Directed by the 5`-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation. J. Biol. Chem. 271: 623-626 [Abstract] [Full Text]  
• Vagner, S.ép., Waysbort, A., Marenda, M., Gensac, M.-C., Amalric, F.ço., Prats, A.-C. (1995). Alternative Translation Initiation of the Moloney Murine Leukemia Virus mRNA Controlled by Internal Ribosome Entry Involving the p57/PTB Splicing Factor. J. Biol. Chem. 270: 20376-20383 [Abstract] [Full Text]  
• Gregorieff, A., Pyronnet, S., Sonenberg, N., Veillette, A. (2000). Regulation of SOCS-1 Expression by Translational Repression. J. Biol. Chem. 275: 21596-21604 [Abstract] [Full Text]