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J Virol. 1989 May; 63(5): 2348-2351

Limited temperature-sensitive transactivation by mutant adenovirus type 2 E1a proteins.

M L Fahnestock and J B Lewis

Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

ABSTRACT

A series of linker-scanning and deletion mutations was generated in the transactivating domain of the larger, 289-amino-acid-residue E1a protein of adenovirus type 2. Mutant genes were recombined into virus to assay the ability of the variant E1a proteins to activate expression of an E1a-dependent viral gene during infection. Results of assays performed at 32, 37, and 40 degrees C indicated that at least 2 of the 10 mutants tested showed limited temperature sensitivity for transactivation.

J Virol. 1989 May; 63(5): 2348-2351






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