This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, C Articles by Linial, M L Search for Related Content PubMed PubMed Citation Articles by Chen, C Articles by Linial, M L

 Previous Article  |  Next Article 

J Virol. 1989 December; 63(12): 5092-5100

FH3, a v-myc avian retrovirus with limited transforming ability.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

ABSTRACT

We have isolated a new acute avian transforming virus which contains the oncogene myc. This virus, designated FH3, was isolated after injection of a 10-day-old chick embryo with avian leukosis virus. While FH3 shares many properties with other v-myc-containing avian retroviruses, it also has several unique properties. The primary target for transformation in vitro is chicken macrophages; infection of chicken fibroblasts does not lead to complete morphological transformation. FH3 also exhibits a limited host range, in that Japanese quail macrophages and fibroblasts are infected but are not completely transformed. FH3 induces in vivo a limited tumor type if injected into 10-day-old chick embryos; only a cranial myelocytoma, which does not appear to be metastatic, can be detected. The v-myc gene of FH3 is expressed predominantly as a P145 Gag-Myc protein which is encoded by a ca. 8-kilobase genomic RNA. This FH3-encoded polyprotein is localized in the nucleus of all infected cells, whether or not they are transformed.

This article has been cited by other articles:

• Hilgemann, D. W., Feng, S., Nasuhoglu, C. (2001). The Complex and Intriguing Lives of PIP2 with Ion Channels and Transporters. Sci Signal 2001: re19-re19 [Abstract] [Full Text]  
• Chesters, P. M., Howes, K., McKay, J. C., Payne, L. N., Venugopal, K. (2001). Acutely Transforming Avian Leukosis Virus Subgroup J Strain 966: Defective Genome Encodes a 72-Kilodalton Gag-Myc Fusion Protein. J. Virol. 75: 4219-4225 [Abstract] [Full Text]  
• Niklinski, J., Claassen, G., Meyers, C., Gregory, M. A., Allegra, C. J., Kaye, F. J., Hann, S. R., Zajac-Kaye, M. (2000). Disruption of Myc-Tubulin Interaction by Hyperphosphorylation of c-Myc during Mitosis or by Constitutive Hyperphosphorylation of Mutant c-Myc in Burkitt's Lymphoma. Mol. Cell. Biol. 20: 5276-5284 [Abstract] [Full Text]