This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tersmette, M Articles by Miedema, F Search for Related Content PubMed PubMed Citation Articles by Tersmette, M Articles by Miedema, F

 Previous Article  |  Next Article 

J Virol. 1988 June; 62(6): 2026-2032

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex.

Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam.

ABSTRACT

Human immunodeficiency virus isolates were studied with respect to syncytium-inducing capacity, replicative properties, and host range. Five of 10 isolates from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex were able to induce syncytia in cultures of peripheral blood mononuclear cells (MNC). In contrast, only 2 of 12 isolates from asymptomatic individuals had syncytium-inducing capacity. Syncytium-inducing isolates were reproducibly obtained from the same MNC sample in over 90% of the cases, independent of the donor MNC used for propagation. Syncytium-inducing capacity was shown to be a stable property of an isolate, independent of viral replication rates. Evidence was obtained that the high replication rate of syncytium-inducing isolates observed during primary isolation may be due to higher infectivity of these isolates. The finding that only syncytium-inducing isolates could be transmitted to the H9 cell line is compatible with this higher infectivity. The frequent isolation of syncytium-inducing isolates from individuals with AIDS-related complex or AIDS and the apparent higher in vitro infectivity of these isolates suggest that syncytium-inducing isolates may unfavorably influence the course of human immunodeficiency virus infection.

This article has been cited by other articles:

• Huang, W., Eshleman, S. H., Toma, J., Fransen, S., Stawiski, E., Paxinos, E. E., Whitcomb, J. M., Young, A. M., Donnell, D., Mmiro, F., Musoke, P., Guay, L. A., Jackson, J. B., Parkin, N. T., Petropoulos, C. J. (2007). Coreceptor Tropism in Human Immunodeficiency Virus Type 1 Subtype D: High Prevalence of CXCR4 Tropism and Heterogeneous Composition of Viral Populations. J. Virol. 81: 7885-7893 [Abstract] [Full Text]  
• Zimbwa, P., Milicic, A., Frater, J., Scriba, T. J., Willis, A., Goulder, P. J. R., Pillay, T., Gunthard, H., Weber, J. N., Zhang, H.-T., Phillips, R. E. (2007). Precise Identification of a Human Immunodeficiency Virus Type 1 Antigen Processing Mutant. J. Virol. 81: 2031-2038 [Abstract] [Full Text]  
• Sundaravaradan, V., Saxena, S. K., Ramakrishnan, R., Yedavalli, V. R. K., Harris, D. T., Ahmad, N. (2006). Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression. Proc. Natl. Acad. Sci. USA 103: 11701-11706 [Abstract] [Full Text]  
• Levy, J.A. (2006). HIV Pathogenesis: Knowledge Gained after Two Decades of Research. Adv. Dent. Res. 19: 10-16 [Abstract] [Full Text]  
• Weinberg, A., Quinones-Mateu, M.E., Lederman, M.M. (2006). Role of Human {beta}-defensins in HIV Infection. Adv. Dent. Res. 19: 42-48 [Abstract] [Full Text]  
• Shi, Y., Brandin, E., Vincic, E., Jansson, M., Blaxhult, A., Gyllensten, K., Moberg, L., Brostrom, C., Fenyo, E. M., Albert, J. (2005). Evolution of human immunodeficiency virus type 2 coreceptor usage, autologous neutralization, envelope sequence and glycosylation. J. Gen. Virol. 86: 3385-3396 [Abstract] [Full Text]  
• Platt, E. J., Durnin, J. P., Kabat, D. (2005). Kinetic Factors Control Efficiencies of Cell Entry, Efficacies of Entry Inhibitors, and Mechanisms of Adaptation of Human Immunodeficiency Virus. J. Virol. 79: 4347-4356 [Abstract] [Full Text]  
• Locher, C. P., Witt, S. A., Kassel, R., Dowell, N. L., Fujimura, S., Levy, J. A. (2005). Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation. J. Gen. Virol. 86: 1171-1179 [Abstract] [Full Text]  
• Blaak, H., Boers, P. H. M., Gruters, R. A., Schuitemaker, H., van der Ende, M. E., Osterhaus, A. D. M. E. (2005). CCR5, GPR15, and CXCR6 Are Major Coreceptors of Human Immunodeficiency Virus Type 2 Variants Isolated from Individuals with and without Plasma Viremia. J. Virol. 79: 1686-1700 [Abstract] [Full Text]  
• Choudhary, S. K., Choudhary, N. R., Kimbrell, K. C., Colasanti, J., Ziogas, A., Kwa, D., Schuitemaker, H., Camerini, D. (2005). R5 Human Immunodeficiency Virus Type 1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression. J. Virol. 79: 458-471 [Abstract] [Full Text]  
• Schweighardt, B., Roy, A.-M., Meiklejohn, D. A., Grace, E. J. II, Moretto, W. J., Heymann, J. J., Nixon, D. F. (2004). R5 Human Immunodeficiency Virus Type 1 (HIV-1) Replicates More Efficiently in Primary CD4+ T-Cell Cultures Than X4 HIV-1. J. Virol. 78: 9164-9173 [Abstract] [Full Text]  
• Pollakis, G., Abebe, A., Kliphuis, A., Chalaby, M. I. M., Bakker, M., Mengistu, Y., Brouwer, M., Goudsmit, J., Schuitemaker, H., Paxton, W. A. (2004). Phenotypic and Genotypic Comparisons of CCR5- and CXCR4-Tropic Human Immunodeficiency Virus Type 1 Biological Clones Isolated from Subtype C-Infected Individuals. J. Virol. 78: 2841-2852 [Abstract] [Full Text]  
• Jensen, M. A., Li, F.-S., van 't Wout, A. B., Nickle, D. C., Shriner, D., He, H.-X., McLaughlin, S., Shankarappa, R., Margolick, J. B., Mullins, J. I. (2003). Improved Coreceptor Usage Prediction and Genotypic Monitoring of R5-to-X4 Transition by Motif Analysis of Human Immunodeficiency Virus Type 1 env V3 Loop Sequences. J. Virol. 77: 13376-13388 [Abstract] [Full Text]  
• Misumi, S., Endo, M., Mukai, R., Tachibana, K., Umeda, M., Honda, T., Takamune, N., Shoji, S. (2003). A Novel Cyclic Peptide Immunization Strategy for Preventing HIV-1/AIDS Infection and Progression. J. Biol. Chem. 278: 32335-32343 [Abstract] [Full Text]  
• Rangel, H. R., Weber, J., Chakraborty, B., Gutierrez, A., Marotta, M. L., Mirza, M., Kiser, P., Martinez, M. A., Este, J. A., Quinones-Mateu, M. E. (2003). Role of the Human Immunodeficiency Virus Type 1 Envelope Gene in Viral Fitness. J. Virol. 77: 9069-9073 [Abstract] [Full Text]  
• Willey, S. J., Reeves, J. D., Hudson, R., Miyake, K., Dejucq, N., Schols, D., Clercq, E. D., Bell, J., McKnight, A., Clapham, P. R. (2003). Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells. J. Virol. 77: 6138-6152 [Abstract] [Full Text]  
• Babcock, G. J., Farzan, M., Sodroski, J. (2003). Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor. J. Biol. Chem. 278: 3378-3385 [Abstract] [Full Text]  
• Hsu, M., Harouse, J. M., Gettie, A., Buckner, C., Blanchard, J., Cheng-Mayer, C. (2002). Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120. J. Virol. 77: 989-998 [Abstract] [Full Text]  
• Ball, S. C., Abraha, A., Collins, K. R., Marozsan, A. J., Baird, H., Quinones-Mateu, M. E., Penn-Nicholson, A., Murray, M., Richard, N., Lobritz, M., Zimmerman, P. A., Kawamura, T., Blauvelt, A., Arts, E. J. (2002). Comparing the Ex Vivo Fitness of CCR5-Tropic Human Immunodeficiency Virus Type 1 Isolates of Subtypes B and C. J. Virol. 77: 1021-1038 [Abstract] [Full Text]  
• Basmaciogullari, S., Babcock, G. J., Van Ryk, D., Wojtowicz, W., Sodroski, J. (2002). Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding. J. Virol. 76: 10791-10800 [Abstract] [Full Text]  
• Clapham, P. R., McKnight, A. (2002). Cell surface receptors, virus entry and tropism of primate lentiviruses. J. Gen. Virol. 83: 1809-1829 [Abstract] [Full Text]  
• Fotopoulos, G., Harari, A., Michetti, P., Trono, D., Pantaleo, G., Kraehenbuhl, J.-P. (2002). Transepithelial transport of HIV-1 by M cells is receptor-mediated. Proc. Natl. Acad. Sci. USA 99: 9410-9414 [Abstract] [Full Text]  
• Reeves, J. D., Doms, R. W. (2002). Human immunodeficiency virus type 2. J. Gen. Virol. 83: 1253-1265 [Full Text]  
• Hoffman, N. G., Seillier-Moiseiwitsch, F., Ahn, J., Walker, J. M., Swanstrom, R. (2002). Variability in the Human Immunodeficiency Virus Type 1 gp120 Env Protein Linked to Phenotype-Associated Changes in the V3 Loop. J. Virol. 76: 3852-3864 [Abstract] [Full Text]  
• Suzuki, J.-i., Miyano-Kurosaki, N., Kuwasaki, T., Takeuchi, H., Kawai, G., Takaku, H. (2002). Inhibition of Human Immunodeficiency Virus Type 1 Activity In Vitro by a New Self-Stabilized Oligonucleotide with Guanosine-Thymidine Quadruplex Motifs. J. Virol. 76: 3015-3022 [Abstract] [Full Text]  
• Baribaud, F., Edwards, T. G., Sharron, M., Brelot, A., Heveker, N., Price, K., Mortari, F., Alizon, M., Tsang, M., Doms, R. W. (2001). Antigenically Distinct Conformations of CXCR4. J. Virol. 75: 8957-8967 [Abstract] [Full Text]  
• Taylor, J. R. Jr., Kimbrell, K. C., Scoggins, R., Delaney, M., Wu, L., Camerini, D. (2001). Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1. J. Virol. 75: 8752-8760 [Abstract] [Full Text]  
• Weber, J. (2001). The pathogenesis of HIV-1 infection. Br Med Bull 58: 61-72 [Abstract] [Full Text]  
• Auewarakul, P., Sangsiriwut, K., Suwanagool, S., Wasi, C. (2001). Target Cell Populations of Human Immunodeficiency Virus Type 1 in Peripheral Blood Lymphocytes with Different Chemokine Receptors at Various Stages of Disease Progression. J. Virol. 75: 6384-6391 [Abstract] [Full Text]  
• Ndung'u, T., Renjifo, B., Essex, M. (2001). Construction and Analysis of an Infectious Human Immunodeficiency Virus Type 1 Subtype C Molecular Clone. J. Virol. 75: 4964-4972 [Abstract] [Full Text]  
• Freel, S. A., Williams, J. M., Nelson, J. A. E., Patton, L. L., Fiscus, S. A., Swanstrom, R., Shugars, D. C. (2001). Characterization of Human Immunodeficiency Virus Type 1 in Saliva and Blood Plasma by V3-Specific Heteroduplex Tracking Assay and Genotype Analyses. J. Virol. 75: 4936-4940 [Abstract] [Full Text]  
• Kelleher, A. D., Long, C., Holmes, E. C., Allen, R. L., Wilson, J., Conlon, C., Workman, C., Shaunak, S., Olson, K., Goulder, P., Brander, C., Ogg, G., Sullivan, J. S., Dyer, W., Jones, I., McMichael, A. J., Rowland-Jones, S., Phillips, R. E. (2001). Clustered Mutations in HIV-1 gag Are Consistently Required for Escape from HLA-B27-restricted Cytotoxic T Lymphocyte Responses. J. Exp. Med. 193: 375-386 [Abstract] [Full Text]  
• Ikuta, K., Suzuki, S., Horikoshi, H., Mukai, T., Luftig, R. B. (2000). Positive and Negative Aspects of the Human Immunodeficiency Virus Protease: Development of Inhibitors versus Its Role in AIDS Pathogenesis. Microbiol. Mol. Biol. Rev. 64: 725-745 [Abstract] [Full Text]  
• Genois, N., Robichaud, G. A, Tremblay, M. J. (2000). Mono Mac 1: a new in vitro model system to study HIV-1 infection in human cells of the mononuclear phagocyte series. J. Leukoc. Biol. 68: 854-864 [Abstract] [Full Text]  
• Dejucq, N., Simmons, G., Clapham, P. R. (2000). T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropism. J. Gen. Virol. 81: 2899-2904 [Abstract] [Full Text]  
• Xiao, H., Neuveut, C., Tiffany, H. L., Benkirane, M., Rich, E. A., Murphy, P. M., Jeang, K.-T. (2000). Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1. Proc. Natl. Acad. Sci. USA 97: 11466-11471 [Abstract] [Full Text]  
• Quiñones-Mateu, M. E., Ball, S. C., Marozsan, A. J., Torre, V. S., Albright, J. L., Vanham, G., van der Groen, G., Colebunders, R. L., Arts, E. J. (2000). A Dual Infection/Competition Assay Shows a Correlation between Ex Vivo Human Immunodeficiency Virus Type 1 Fitness and Disease Progression. J. Virol. 74: 9222-9233 [Abstract] [Full Text]  
• Dejucq, N. (2000). HIV-1 replication in CD4+ T cell lines: the effects of adaptation on co-receptor use, tropism, and accessory gene function. J. Leukoc. Biol. 68: 331-337 [Abstract] [Full Text]  
• Moriuchi, H., Moriuchi, M., Fauci, A. S. (2000). Cathepsin G, a Neutrophil-Derived Serine Protease, Increases Susceptibility of Macrophages to Acute Human Immunodeficiency Virus Type 1 Infection. J. Virol. 74: 6849-6855 [Abstract] [Full Text]  
• Hendrix, C. W., Flexner, C., MacFarland, R. T., Giandomenico, C., Fuchs, E. J., Redpath, E., Bridger, G., Henson, G. W. (2000). Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR-4 Chemokine Receptor, in Human Volunteers. Antimicrob. Agents Chemother. 44: 1667-1673 [Abstract] [Full Text]  
• Camerini, D., Su, H.-P., Gamez-Torre, G., Johnson, M. L., Zack, J. A., Chen, I. S. Y. (2000). Human Immunodeficiency Virus Type 1 Pathogenesis in SCID-hu Mice Correlates with Syncytium-Inducing Phenotype and Viral Replication. J. Virol. 74: 3196-3204 [Abstract] [Full Text]  
• Scoggins, R. M., Taylor, J. R. Jr., Patrie, J., van't Wout, A. B., Schuitemaker, H., Camerini, D. (2000). Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice. J. Virol. 74: 3205-3216 [Abstract] [Full Text]  
• Annunziato, F., Galli, G., Nappi, F., Cosmi, L., Manetti, R., Maggi, E., Ensoli, B., Romagnani, S. (2000). Limited expression of R5-tropic HIV-1 in CCR5-positive type 1-polarized T cells explained by their ability to produce RANTES, MIP-1alpha , and MIP-1beta. Blood 95: 1167-1174 [Abstract] [Full Text]  
• Holterman, L., Niphuis, H., ten Haaft, P. J. F., Goudsmit, J., Baskin, G., Heeney, J. L. (1999). Specific passage of simian immunodeficiency virus fromend-stage disease results in accelerated progression to AIDS in rhesus macaques. J. Gen. Virol. 80: 3089-3097 [Abstract] [Full Text]  
• Cutrona, G., Leanza, N., Ulivi, M., Melioli, G., Burgio, V. L., Mazzarello, G., Gabutti, G., Roncella, S., Ferrarini, M. (1999). Expression of CD10 by Human T Cells That Undergo Apoptosis Both In Vitro and In Vivo. Blood 94: 3067-3076 [Abstract] [Full Text]  
• de Roda Husman, A.-M., Blaak, H., Brouwer, M., Schuitemaker, H. (1999). CC Chemokine Receptor 5 Cell-Surface Expression in Relation to CC Chemokine Receptor 5 Genotype and the Clinical Course of HIV-1 Infection. J. Immunol. 163: 4597-4603 [Abstract] [Full Text]  
• Dejucq, N., Simmons, G., Clapham, P. R. (1999). Expanded Tropism of Primary Human Immunodeficiency Virus Type 1 R5 Strains to CD4+ T-Cell Lines Determined by the Capacity To Exploit Low Concentrations of CCR5. J. Virol. 73: 7842-7847 [Abstract] [Full Text]  
• Poss, M., Overbaugh, J. (1999). Variants from the Diverse Virus Population Identified at Seroconversion of a Clade A Human Immunodeficiency Virus Type 1-Infected Woman Have Distinct Biological Properties. J. Virol. 73: 5255-5264 [Abstract] [Full Text]  
• Kato, K., Sato, H., Takebe, Y. (1999). Role of Naturally Occurring Basic Amino Acid Substitutions in the Human Immunodeficiency Virus Type 1 Subtype E Envelope V3 Loop on Viral Coreceptor Usage and Cell Tropism. J. Virol. 73: 5520-5526 [Abstract] [Full Text]  
• Esté, J. A., Cabrera, C., Blanco, J., Gutierrez, A., Bridger, G., Henson, G., Clotet, B., Schols, D., De Clercq, E. (1999). Shift of Clinical Human Immunodeficiency Virus Type 1 Isolates from X4 to R5 and Prevention of Emergence of the Syncytium-Inducing Phenotype by Blockade of CXCR4. J. Virol. 73: 5577-5585 [Abstract] [Full Text]  
• Canque, B., Bakri, Y., Camus, S., Yagello, M., Benjouad, A., Gluckman, J. C. (1999). The Susceptibility to X4 and R5 Human Immunodeficiency Virus-1 Strains of Dendritic Cells Derived In Vitro From CD34+ Hematopoietic Progenitor Cells Is Primarily Determined by Their Maturation Stage. Blood 93: 3866-3875 [Abstract] [Full Text]  
• Sato, H., Shiino, T., Kodaka, N., Taniguchi, K., Tomita, Y., Kato, K., Miyakuni, T., Takebe, Y. (1999). Evolution and Biological Characterization of Human Immunodeficiency Virus Type 1 Subtype E gp120 V3 Sequences following Horizontal and Vertical Virus Transmission in a Single Family. J. Virol. 73: 3551-3559 [Abstract] [Full Text]  
• Voulgaropoulou, F., Tan, B., Soares, M., Hahn, B., Ratner, L. (1999). Distinct Human Immunodeficiency Virus Strains in the Bone Marrow Are Associated with the Development of Thrombocytopenia. J. Virol. 73: 3497-3504 [Abstract] [Full Text]  
• Chan, S. Y., Speck, R. F., Power, C., Gaffen, S. L., Chesebro, B., Goldsmith, M. A. (1999). V3 Recombinants Indicate a Central Role for CCR5 as a Coreceptor in Tissue Infection by Human Immunodeficiency Virus Type 1. J. Virol. 73: 2350-2358 [Abstract] [Full Text]  
• Greco, G., Fujimura, S. H., Mourich, D. V., Levy, J. A. (1999). Differential Effects of Human Immunodeficiency Virus Isolates on beta -Chemokine and Gamma Interferon Production and on Cell Proliferation. J. Virol. 73: 1528-1534 [Abstract] [Full Text]  
• Suzuki, Y., Koyanagi, Y., Tanaka, Y., Murakami, T., Misawa, N., Maeda, N., Kimura, T., Shida, H., Hoxie, J. A., O'Brien, W. A., Yamamoto, N. (1999). Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions. J. Virol. 73: 316-324 [Abstract] [Full Text]  
• Berkowitz, R. D., Alexander, S., Bare, C., Linquist-Stepps, V., Bogan, M., Moreno, M. E., Gibson, L., Wieder, E. D., Kosek, J., Stoddart, C. A., McCune, J. M. (1998). CCR5- and CXCR4-Utilizing Strains of Human Immunodeficiency Virus Type 1 Exhibit Differential Tropism and Pathogenesis In Vivo. J. Virol. 72: 10108-10117 [Abstract] [Full Text]  
• Grovit-Ferbas, K., Ferbas, J., Gudeman, V., Sadeghi, S., Goetz, M. B., Giorgi, J. V., Chen, I. S. Y., O'Brien, W. A. (1998). Potential Contributions of Viral Envelope and Host Genetic Factors in a Human Immunodeficiency Virus Type 1-Infected Long-Term Survivor. J. Virol. 72: 8650-8658 [Abstract] [Full Text]  
• Zhang, Y.-j., Dragic, T., Cao, Y., Kostrikis, L., Kwon, D. S., Littman, D. R., KewalRamani, V. N., Moore, J. P. (1998). Use of Coreceptors Other Than CCR5 by Non-Syncytium-Inducing Adult and Pediatric Isolates of Human Immunodeficiency Virus Type 1 Is Rare In Vitro. J. Virol. 72: 9337-9344 [Abstract] [Full Text]  
• Pinto, L. A., Sharpe, S., Cohen, D. I., Shearer, G. M. (1998). Alloantigen-Stimulated Anti-HIV Activity. Blood 92: 3346-3354 [Abstract] [Full Text]  
• Yu, H., Jetzt, A. E., Ron, Y., Preston, B. D., Dougherty, J. P. (1998). The Nature of Human Immunodeficiency Virus Type 1 Strand Transfers. J. Biol. Chem. 273: 28384-28391 [Abstract] [Full Text]  
• Simmons, G., Reeves, J. D., McKnight, A., Dejucq, N., Hibbitts, S., Power, C. A., Aarons, E., Schols, D., De Clercq, E., Proudfoot, A. E. I., Clapham, P. R. (1998). CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages. J. Virol. 72: 8453-8457 [Abstract] [Full Text]  
• Verani, A., Pesenti, E., Polo, S., Tresoldi, E., Scarlatti, G., Lusso, P., Siccardi, A. G., Vercelli, D. (1998). Cutting Edge: CXCR4 Is a Functional Coreceptor for Infection of Human Macrophages by CXCR4-Dependent Primary HIV-1 Isolates. J. Immunol. 161: 2084-2088 [Abstract] [Full Text]  
• Schmidtmayerova, H., Alfano, M., Nuovo, G., Bukrinsky, M. (1998). Human Immunodeficiency Virus Type 1 T-Lymphotropic Strains Enter Macrophages via a CD4- and CXCR4-Mediated Pathway: Replication Is Restricted at a Postentry Level. J. Virol. 72: 4633-4642 [Abstract] [Full Text]  
• Sullivan, N., Sun, Y., Sattentau, Q., Thali, M., Wu, D., Denisova, G., Gershoni, J., Robinson, J., Moore, J., Sodroski, J. (1998). CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization. J. Virol. 72: 4694-4703 [Abstract] [Full Text]  
• Zhang, L., He, T., Talal, A., Wang, G., Frankel, S. S., Ho, D. D. (1998). In Vivo Distribution of the Human Immunodeficiency Virus/Simian Immunodeficiency Virus Coreceptors: CXCR4, CCR3, and CCR5. J. Virol. 72: 5035-5045 [Abstract] [Full Text]  
• Moriuchi, H., Moriuchi, M., Fauci, A. S. (1998). Factors Secreted by Human T Lymphotropic Virus Type I (HTLV-I)-infected Cells Can Enhance or Inhibit Replication of HIV-1 in HTLV-I-uninfected Cells: Implications for In Vivo Coinfection with HTLV-I and HIV-1. J. Exp. Med. 187: 1689-1697 [Abstract] [Full Text]  
• Sawada, S., Gowrishankar, K., Kitamura, R., Suzuki, M., Suzuki, G., Tahara, S., Koito, A. (1998). Disturbed CD4+ T Cell Homeostasis and In Vitro HIV-1 Susceptibility in Transgenic Mice Expressing T Cell Line-tropic HIV-1 Receptors. J. Exp. Med. 187: 1439-1449 [Abstract] [Full Text]  
• McKnight, A., Dittmar, M. T., Moniz-Periera, J., Ariyoshi, K., Reeves, J. D., Hibbitts, S., Whitby, D., Aarons, E., Proudfoot, A. E. I., Whittle, H., Clapham, P. R. (1998). A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4. J. Virol. 72: 4065-4071 [Abstract] [Full Text]  
• Rohn, J. L., Moser, M. S., Gwynn, S. R., Baldwin, D. N., Overbaugh, J. (1998). In Vivo Evolution of a Novel, Syncytium-Inducing and Cytopathic Feline Leukemia Virus Variant. J. Virol. 72: 2686-2696 [Abstract] [Full Text]  
• Cavaco-Silva, P., Taveira, N. C., Rosado, L., Lourenco, M. H., Moniz-Pereira, J., Douglas, N. W., Daniels, R. S., Santos-Ferreira, M. O. (1998). Virological and Molecular Demonstration of Human Immunodeficiency Virus Type 2 Vertical Transmission. J. Virol. 72: 3418-3422 [Abstract] [Full Text]  
• Trkola, A., Ketas, T., KewalRamani, V. N., Endorf, F., Binley, J. M., Katinger, H., Robinson, J., Littman, D. R., Moore, J. P. (1998). Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage. J. Virol. 72: 1876-1885 [Abstract] [Full Text]  
• Picchio, G. R., Gulizia, R. J., Wehrly, K., Chesebro, B., Mosier, D. E. (1998). The Cell Tropism of Human Immunodeficiency Virus Type 1 Determines the Kinetics of Plasma Viremia in SCID Mice Reconstituted with Human Peripheral Blood Leukocytes. J. Virol. 72: 2002-2009 [Abstract] [Full Text]  
• Kimata, J. T., Mozaffarian, A., Overbaugh, J. (1998). A Lymph Node-Derived Cytopathic Simian Immunodeficiency Virus Mne Variant Replicates in Nonstimulated Peripheral Blood Mononuclear Cells. J. Virol. 72: 245-256 [Abstract] [Full Text]  
• van't Wout, A. B., Ran, L. J., Kuiken, C. L., Kootstra, N. A., Pals, S. T., Schuitemaker, H. (1998). Analysis of the Temporal Relationship between Human Immunodeficiency Virus Type 1 Quasispecies in Sequential Blood Samples and Various Organs Obtained at Autopsy. J. Virol. 72: 488-496 [Abstract] [Full Text]  
• Connor, R. I., Sheridan, K. E., Ceradini, D., Choe, S., Landau, N. R. (1997). Change in Coreceptor Use Correlates with Disease Progression in HIV-1-Infected Individuals. J. Exp. Med. 185: 621-628 [Abstract] [Full Text]  
• Jansson, M., Popovic, M., Karlsson, A., Cocchi, F., Rossi, P., Albert, J., Wigzell, H. (1996). Sensitivity to inhibition by beta -chemokines correlates with biological phenotypes of primary HIV-1 isolates. Proc. Natl. Acad. Sci. USA 93: 15382-15387 [Abstract] [Full Text]  
• Freed, E. O., Martin, M. A. (1995). The Role of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins in Virus Infection. J. Biol. Chem. 270: 23883-23886 [Full Text]  
• Callebaut, C., Jacotot, E., Krust, B., Hovanessian, A. G. (1994). Response. Science 264: 1162-1165  
• Zhu, T, Mo, H, Wang, N, Nam, D., Cao, Y, Koup, R., Ho, D. (1993). Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 261: 1179-1181 [Abstract]  
• Mosier, D., Gulizia, R., MacIsaac, P., Torbett, B., Levy, J. (1993). Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260: 689-692 [Abstract]  
• Strebel, K, Klimkait, T, Martin, M. (1988). A novel gene of HIV-1, vpu, and its 16-kilodalton product. Science 241: 1221-1223 [Abstract]  
• Pollakis, G., Kang, S., Kliphuis, A., Chalaby, M. I. M., Goudsmit, J., Paxton, W. A. (2001). N-Linked Glycosylation of the HIV Type-1 gp120 Envelope Glycoprotein as a Major Determinant of CCR5 and CXCR4 Coreceptor Utilization. J. Biol. Chem. 276: 13433-13441 [Abstract] [Full Text]