This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Eckner, R J Articles by Seidler, C Search for Related Content PubMed PubMed Citation Articles by Eckner, R J Articles by Seidler, C

Natural killer cell suppression of Friend virus-induced preleukemic hemopoietic stem cells.

ABSTRACT

To determine whether hemopoietic cells infected with Friend polycythemia-inducing spleen focus-forming virus (SFFVp) are conserved or suppressed via natural surveillance in leukemia-resistant adult mice, we engrafted C57BL/6 recipients with isologous transgenic (donor origin marker) or natural killer (NK) cell-deficient B6 beige marrow cells exposed to SFFVp in vitro. Both groups of primary recipients were viremic and nonleukemic. Spleen cells from primary SFFVp-infected chimeras were engrafted into irradiated leukemia-susceptible secondary recipients to reveal dormant leukemia and grew as tumors of donor origin in 8 of 38 (21%) and 33 of 47 (70%) instances, respectively. Treatment of marrow donors and recipients with anti-asialo GM1 serum resulted in the depression of NK cell activity and the rapid development of dormant leukemia. We conclude that NK cells are an effective surveillance mechanism able to suppress SFFVp-induced preleukemic stem cells.

This article has been cited by other articles:

• Kim, T. W., Lee, T. Y., Bae, H. C., Hahm, J. H., Kim, Y. H., Park, C., Kang, T. H., Kim, C. J., Sung, M. H., Poo, H. (2007). Oral Administration of High Molecular Mass Poly-{gamma}-Glutamate Induces NK Cell-Mediated Antitumor Immunity. J. Immunol. 179: 775-780 [Abstract] [Full Text]