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J Virol. 1986 November; 60(2): 761-764

Complex formation of simian virus 40 large T antigen with cellular protein p53.

M Montenarh, M Kohler and R Henning

ABSTRACT

We investigated the formation of native complexes between simian virus 40 large T antigen and the cellular protein p53 (T-p53) by using simian virus 40 tsA58-transformed mouse fibroblasts (tsA58 F2b). We observed that newly synthesized p53 bound to all structural subclasses of large T antigen detectable on sucrose density gradients. This led to various intermediates of T-p53 complexes which converted within 2 h into typical mature aggregates. The final levels of stable T-p53 complexes seemed to be determined by p53 rather than by large T antigen.

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J Virol. 1986 November; 60(2): 761-764

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