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Susceptibility of Human Cell Strains to Transformation by Simian Virus 40 and Simian Virus 40 Deoxyribonucleic Acid

Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

ABSTRACT

Marked differences were found in the susceptibility of human fibroblasts to transformation by simian virus 40 (SV40). Highly susceptible cell strains were derived from patients with diseases associated with chromosomal abnormalities and a high incidence of tumors. In the present study, SV40 transformation-susceptible cell strains were not found to have a generalized increase in viral sensitivity. The differences in transformation frequency among cell strains with whole virus are eliminated by the use of isolated SV40 deoxyribonucleic acid, suggesting that the relative resistance of most cell strains to transformation by whole virus is due to a block at an early step in infection.

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