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J Virol. 1970 July; 6(1): 78-86
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Early Events in the Infection of Permissive Cells with Simian Virus 40: Adsorption, Penetration, and Uncoating

The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104

ABSTRACT

The early events in the interaction of simian virus 40 (SV40) with permissive cells were investigated. Evidence is presented that 30 min after infection intact virions penetrate the nuclei of infected cells. The uncoating of the virus is carried out in the nuclei with a complete dissociation of the viral genome from the protein coat. Opening of the circular parental deoxyribonucleic acid (DNA), i.e., conversion of component I to component II of SV40 DNA, takes place after uncoating, followed by the appearance of a new component sedimenting faster than component I at alkaline pH.

¹ Fellow of The Wistar Institute from the Institute of Microbiology, University of Bologna, Bologna, Italy.

² Fellow of The Wistar Institute from the Institut für Biochemie, University of Vienna, Vienna, Austria.

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