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J Virol. 1970 July; 6(1): 100-106
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Structure and Cytopathic Effects of Nelson Bay Virus

Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T., Australia

ABSTRACT

A virus isolated from a flying fox (Pteropus poliocephalus) has a morphology similar to that of reoviruses. However, unlike the reoviruses, this virus has a rapid cytopathic effect, causing cell fusion, vacuolization of the cytoplasm, and an unusual nuclear degeneration. Immunofluorescence indicates that viral antigen is distributed through both nucleus and cytoplasm. Viral maturation appears to take place in discrete cytoplasmic factories, and there is no apparent involvement of spindle tubules.

¹ Present address: The Rockefeller University, New York, N.Y. 10021.

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