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J Virol. 1986 July; 59(1): 45-49

Sequences near the 5' long terminal repeat of avian leukosis viruses determine the ability to induce osteopetrosis.

H L Robinson, S S Reinsch and P R Shank

ABSTRACT

Avian leukosis virus (ALV)-induced osteopetrosis is associated with the accumulation of unintegrated viral DNA in osteoblasts. Viruses constructed from the DNAs of an osteopetrosis-inducing ALV (Br21) and a non-osteopetrosis-inducing ALV (RAV-0) have been used to test for the role of viral genes in the induction of osteopetrosis. Our results map osteopetrotic potential to a 1,400-base-pair region near the 5' long terminal repeat. This region contains signals for the splicing, translation, and packaging of viral RNAs and coding sequences for the gag proteins p19 and p10 and the N terminus of p27.

J Virol. 1986 July; 59(1): 45-49






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Copyright © 1986 by the American Society for Microbiology. All rights reserved.