This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Horvath, J Articles by Weber, J Search for Related Content PubMed PubMed Citation Articles by Horvath, J Articles by Weber, J

 Previous Article  |  Next Article 

J Virol. 1986 July; 59(1): 189-192

Group C adenovirus DNA sequences in human lymphoid cells.

ABSTRACT

Human peripheral blood lymphocytes from healthy adults, cord blood lymphocytes, and lymphoblastoid cell lines were screened by hybridization for the presence of group C adenovirus DNA sequences. In 13 of 17 peripheral blood lymphocyte samples from adults, 1 of 10 cord blood samples, and seven of seven lymphoblastoid cell lines tested, results were positive for Group C adenovirus DNA (adenovirus 1 [Ad1], Ad2, Ad5, or Ad6). About 1 to 2% of the lymphocytes carried 50 to 100 viral genome copies per positive cell, as estimated by in situ hybridization. Infectious virus representing all members of group C were recovered, but cultivation in the presence of adenovirus antibody did not cure the cells of free viral genomes. Viral DNA was found in B, T, and N cells but only in 1 of 10 cord blood samples. The results suggest that group C adenovirus infections in childhood result in the persistence of the viral genome in circulating lymphocytes.

This article has been cited by other articles:

• Shah, A. H., Cianciola, N. L., Mills, J. L., Sonnichsen, F. D., Carlin, C. (2007). Adenovirus RID{alpha} regulates endosome maturation by mimicking GTP-Rab7. J. Cell Biol. 179: 965-980 [Abstract] [Full Text]  
• Kosulin, K., Haberler, C., Hainfellner, J. A., Amann, G., Lang, S., Lion, T. (2007). Investigation of Adenovirus Occurrence in Pediatric Tumor Entities. J. Virol. 81: 7629-7635 [Abstract] [Full Text]  
• Leen, A. M., Sili, U., Savoldo, B., Jewell, A. M., Piedra, P. A., Brenner, M. K., Rooney, C. M. (2004). Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications. Blood 103: 1011-1019 [Abstract] [Full Text]  
• Moise, A. R., Grant, J. R., Vitalis, T. Z., Jefferies, W. A. (2002). Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release. J. Virol. 76: 1578-1587 [Abstract] [Full Text]  
• HOGG, J. C. (2001). Role of Latent Viral Infections in Chronic Obstructive Pulmonary Disease and Asthma. Am. J. Respir. Crit. Care Med. 164: S71-75 [Abstract] [Full Text]  
• Gilmour, P. S., Rahman, I., Hayashi, S., Hogg, J. C., Donaldson, K., MacNee, W. (2001). Adenoviral E1A primes alveolar epithelial cells to PM10-induced transcription of interleukin-8. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L598-L606 [Abstract] [Full Text]  
• RETAMALES, I., ELLIOTT, W. M., MESHI, B., COXSON, H. O., PARE, P. D., SCIURBA, F. C., ROGERS, R. M., HAYASHI, S., HOGG, J. C. (2001). Amplification of Inflammation in Emphysema and Its Association with Latent Adenoviral Infection. Am. J. Respir. Crit. Care Med. 164: 469-473 [Abstract] [Full Text]  
• Sanchez, T. A., Habib, I., Leland Booth, J., Evetts, S. M., Metcalf, J. P. (2000). Zinc Finger and Carboxyl Regions of Adenovirus E1A 13S CR3 Are Important for Transactivation of the Cytomegalovirus Major Immediate Early Promoter by Adenovirus. Am. J. Respir. Cell Mol. Bio. 23: 670-677 [Abstract] [Full Text]  
• Hogg, J. C. (2000). Latent Adenoviral Infection in the Pathogenesis of Emphysema : The Parker B. Francis Lectureship. Chest 117: 282S-285S [Full Text]  
• Schaley, J., O'Connor, R. J., Taylor, L. J., Bar-Sagi, D., Hearing, P. (2000). Induction of the Cellular E2F-1 Promoter by the Adenovirus E4-6/7 Protein. J. Virol. 74: 2084-2093 [Abstract] [Full Text]  
• Krieg, A. M., Wu, T., Weeratna, R., Efler, S. M., Love-Homan, L., Yang, L., Yi, A.-K., Short, D., Davis, H. L. (1998). Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc. Natl. Acad. Sci. USA 95: 12631-12636 [Abstract] [Full Text]  
• Kajon, A. E., Brown, C. C., Spindler, K. R. (1998). Distribution of Mouse Adenovirus Type 1 in Intraperitoneally and Intranasally Infected Adult Outbred Mice. J. Virol. 72: 1219-1223 [Abstract] [Full Text]