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J Virol. 1986 July; 59(1): 168-171

Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice.

ABSTRACT

Neutralizing and nonneutralizing monoclonal antibodies to the peplomer glycoprotein and nucleocapsid protein of a mouse hepatitis virus (MHV), MHV-NuU, protected mice against lethal MHV-2 challenge. Histopathologically, livers of mice receiving protective antibodies showed some focal necrotic lesions with remarkable cellular infiltration instead of fulminant hepatitis caused by MHV-2.

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