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J Virol. 1986 June; 58(3): 782-789

Evidence for H-2-linked control of retrovirus production in Friend virus-induced tumor cell lines.

J H Wolfe and K J Blank

ABSTRACT

In Friend leukemia virus-induced tumor cell lines derived from mice congenic with respect to the H-2 complex, most cell lines expressing the H-2k haplotype continuously produced infectious exogenous virus in culture, whereas most cell lines expressing the H-2b or H-2d haplotype stopped producing virus during in vitro passage. This apparent H-2-linked control of virus production did not appear to be the result of alteration of the provirus or resistance to superinfection. The implications of this finding with respect to virus-induced leukemogenesis are discussed.

J Virol. 1986 June; 58(3): 782-789






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