This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miller, A D Articles by Curran, T Search for Related Content PubMed PubMed Citation Articles by Miller, A D Articles by Curran, T

 Previous Article  |  Next Article 

J Virol. 1985 September; 55(3): 521-526

Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity.

ABSTRACT

Both FBJ murine osteosarcoma virus (FBJ-MSV) and FBR-MSV induce transformation in tissue culture and osteogenic sarcomas in mice. In tissue culture, however, FBR-MSV induces larger foci with a shorter latency than those induced by FBJ-MSV. Transformation is dependent on expression of the fos oncogene in FBJ-MSV and of a gag-fos fusion protein in FBR-MSV. We have determined that the gag sequences can be deleted from FBR-MSV without affecting the high transforming activity of this virus in comparison to FBJ-MSV. The resultant virus, designated FBJ/R-MSV, has a protein coding region that is half the size of that of FBR-MSV and about one-third smaller than that of FBJ-MSV. Thus, FBJ/R-MSV will provide a useful tool for studying the transforming activity of the fos oncogene.

This article has been cited by other articles:

• Scott, L. A., Vass, J. K., Parkinson, E. K., Gillespie, D. A. F., Winnie, J. N., Ozanne, B. W. (2004). Invasion of Normal Human Fibroblasts Induced by v-Fos Is Independent of Proliferation, Immortalization, and the Tumor Suppressors p16INK4a and p53. Mol. Cell. Biol. 24: 1540-1559 [Abstract] [Full Text]  
• Liu, S.-L., Lerman, M. I., Miller, A. D. (2003). Putative Phosphatidylinositol 3-Kinase (PI3K) Binding Motifs in Ovine Betaretrovirus Env Proteins Are Not Essential for Rodent Fibroblast Transformation and PI3K/Akt Activation. J. Virol. 77: 7924-7935 [Abstract] [Full Text]  
• Lin, X., Zhang, F., Bradbury, C. M., Kaushal, A., Li, L., Spitz, D. R., Aft, R. L., Gius, D. (2003). 2-Deoxy-D-Glucose-induced Cytotoxicity and Radiosensitization in Tumor Cells Is Mediated via Disruptions in Thiol Metabolism. Cancer Res. 63: 3413-3417 [Abstract] [Full Text]  
• Liu, S.-L., Duh, F.-M., Lerman, M. I., Miller, A. D. (2003). Role of Virus Receptor Hyal2 in Oncogenic Transformation of Rodent Fibroblasts by Sheep Betaretrovirus Env Proteins. J. Virol. 77: 2850-2858 [Abstract] [Full Text]  
• Dirks, C., Duh, F.-M., Rai, S. K., Lerman, M. I., Miller, A. D. (2002). Mechanism of Cell Entry and Transformation by Enzootic Nasal Tumor Virus. J. Virol. 76: 2141-2149 [Abstract] [Full Text]  
• Rai, S. K., Duh, F.-M., Vigdorovich, V., Danilkovitch-Miagkova, A., Lerman, M. I., Miller, A. D. (2001). Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc. Natl. Acad. Sci. USA 98: 4443-4448 [Abstract] [Full Text]  
• Bakin, A. V., Curran, T. (1999). Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos. Science 283: 387-390 [Abstract] [Full Text]  
• Kim, H., Lee, H., Yun, Y. (1998). X-gene Product of Hepatitis B Virus Induces Apoptosis in Liver Cells. J. Biol. Chem. 273: 381-385 [Abstract] [Full Text]  
• Andresson, T., Sparkowski, J., Goldstein, D. J., Schlegel, R. (1995). Vacuolar H[IMAGE]-ATPase Mutants Transform Cells and Define a Binding Site for the Papillomavirus E5 Oncoprotein. J. Biol. Chem. 270: 6830-6837 [Abstract] [Full Text]