This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mocarski, E S Articles by Frenkel, N Search for Related Content PubMed PubMed Citation Articles by Mocarski, E S Articles by Frenkel, N

 Previous Article  |  Next Article 

J Virol. 1985 July; 55(1): 140-146

Nucleotide sequence and structural features of a novel US-a junction present in a defective herpes simplex virus genome.

ABSTRACT

Defective genomes generated during serial propagation of herpes simplex virus type 1 (Justin) consist of tandem reiterations of sequences that are colinear with a portion of the S component of the standard viral genome. We determined the structure of the novel US-a junction, at which the US sequences of one repeat unit join the a sequences of the adjacent repeat unit. Comparison of the nucleotide sequence at this junction with the nucleotide sequence of the corresponding US region of the standard virus genome indicated that the defective genome repeat unit arose by a single recombinational event between an L-S junction a sequence and the US region. The recombinational process might have been mediated by limited sequence homology. The sequences retained within the US-a junction further define the signal for cleavage and packaging of viral DNA.

This article has been cited by other articles:

• Umene, K., Oohashi, S., Yoshida, M., Fukumaki, Y. (2008). Diversity of the a sequence of herpes simplex virus type 1 developed during evolution. J. Gen. Virol. 89: 841-852 [Abstract] [Full Text]  
• Umene, K., Kawana, T. (2003). Divergence of reiterated sequences in a series of genital isolates of herpes simplex virus type 1 from individual patients. J. Gen. Virol. 84: 917-923 [Abstract] [Full Text]  
• Huang, K.-J., Zemelman, B. V., Lehman, I. R. (2002). Endonuclease G, a Candidate Human Enzyme for the Initiation of Genomic Inversion in Herpes Simplex Type 1 Virus. J. Biol. Chem. 277: 21071-21079 [Abstract] [Full Text]  
• Umene, K. (2001). Cleavage in and around the DR1 Element of the a Sequence of Herpes Simplex Virus Type 1 Relevant to the Excision of DNA Fragments with Length Corresponding to One and Two Units of the a Sequence. J. Virol. 75: 5870-5878 [Abstract] [Full Text]  
• Adelman, K., Salmon, B., Baines, J. D. (2001). Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery. Proc. Natl. Acad. Sci. USA 98: 3086-3091 [Abstract] [Full Text]