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J Virol. 1984 July; 51(1): 254-258

Structural proteins of Chikungunya virus.

ABSTRACT

Polyacrylamide gel analysis of the structural proteins of African and Asian strains of Chikungunya virus, an alphavirus, showed that both strains contain three structural proteins: glycosylated E1 and E2, embedded in the viral envelope, and a nonglycosylated nucleocapsid protein. In pulse-chase experiments the precursor protein PE2 was chased into glycoprotein E2, which migrated slightly faster than did glycoprotein E1. The third Chikungunya glycoprotein, E3, was not associated with mature virions but was released into culture fluids. With glycoproteins E1 and E2, separated by glass wool column chromatography, it was shown that hemagglutinating activity is associated with glycoprotein E1.

This article has been cited by other articles:

• Powers, A. M., Logue, C. H. (2007). Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J. Gen. Virol. 88: 2363-2377 [Full Text]