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J Virol. 1984 June; 50(3): 943-946

DNA binding properties of a mutant T antigen from the simian virus 40-transformed human cell line simian virus 80.

C Gruss, E Baumann and R Knippers

ABSTRACT

We investigated whether the T antigen of the simian virus 40-transformed human cell line simian virus 80 ( SV80 ) specifically recognizes DNA sequences of its own template, i.e, the viral sequences integrated in the SV80 cellular genome. In vitro DNA binding experiments clearly indicated that, in contrast to wild-type T antigen, SV80 T antigen does not specifically bind to sites on the integrated viral DNA in SV80 cells.

J Virol. 1984 June; 50(3): 943-946






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