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J Virol. 1984 April; 50(1): 280-283

Neoplastic transformation by E26 leukemia virus is mediated by a single protein containing domains of gag and myb genes.

K H Klempnauer and J M Bishop

ABSTRACT

The genome of avian leukemia virus E26 shares homology with v-myb, the oncogene of avian myeloblastosis virus, and encodes a protein with an Mr of 135,000. Analyses of tryptic oligopeptides show that this protein is related to the proteins encoded by gag (Pr76gag) as well as v-myb (p45v-myb[AMV] ) and c-myb (p75c-myb). We found no evidence for the existence of additional myb-related proteins or subgenomic species of myb-related RNA in myeloblasts transformed by strain E26.

J Virol. 1984 April; 50(1): 280-283






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J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1984 by the American Society for Microbiology. All rights reserved.