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Human-Mouse Hybrid Cell Lines and Susceptibility to Polio Virus ¹

II. Polio Sensitivity and the Chromosome Constitution of the Hybrids

Departments of Cell Biology and Pathology, New York University School of Medicine, New York, New York 10016

ABSTRACT

A number of human-mouse hybrid cell lines with partial human chromosome complements were sensitive to poliovirus because the cells contained the viral receptor substance of human origin. Infection of the lines with one type of poliovirus regularly led to the survival of a few cells, whose progeny were found to be resistant to all types of poliovirus. Comparison of the chromosomes of sensitive hybrids and their resistant sublines showed no consistent difference in the number of biarmed human chromosomes of any group. The number of acrocentrics was always lower in the resistant hybrids than in the corresponding sensitive lines. It is suggested that the human chromosome bearing the polio receptor gene is an acrocentric.

² Present address: Research Institute for Tuberculosis, Leprosy and Cancer, Tohoku University, Sendai, Japan.

³ Fellow of the National Cancer Institute (5F02 CA40936).

¹ Aided by grants from the National Cancer Institute.