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J Virol. 1970 February; 5(2): 226-229
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Host-Cell Lysosomal Response to Two Strains of Herpes Simplex Virus ¹

Department of Microbiology, The Pennsylvania State University, University Park, Pennsylvania 16802

ABSTRACT

A correlation has been made between the host lysosomal responses to and release of infectious virus from HEp-2 cells infected with two strains of herpes simplex virus (HSV). Supravital staining with acridine orange was used for morphological studies of macroplaque and microplaque HSV-infected cells. With the progression of infection, cells infected with either microplaque HSV or macroplaque HSV were observed to undergo different lysosomal and cytopathic changes, which could be correlated with increased accumulation of acid phosphatase and infectious virus in the extracellular fluid.

² Present address: Virus and Rickettsia Division, Fort Detrick, Frederick, Md. 21701.

¹ Presented in part at the 69th Annual Meeting of the American Society for Microbiology, Miami, Fia., 4-9 May 1969 (Bacteriol. Proc. p. 164, 1969). Authorized for publication on August 27, 1969 as paper no. 3650 in the journal series of the Pennsylvania Agricultural Experiment Station.