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J Virol. 1970 February; 5(2): 221-225
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Host-Range Restrictions of Murine Leukemia Viruses in Mouse Embryo Cell Cultures

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, and Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

ABSTRACT

Murine leukemia virus strains fall into three categories with respect to their ability to propagate in cells of National Institutes of Health (NIH) Swiss and BALB/c mouse embryos. Cultures of NIH cells are 100- to 1,000-fold more sensitive to "N-tropic" strains than BALB/c cell cultures, but are 30- to 100-fold less sensitive to "B-tropic" strains. Some virus strains (dually tropic or "NB-tropic") propagate equally well in both cells. M-MSV pseudotypes show the host-range characteristics of the virus supplying the envelope, both in vitro and in vivo. The host-range characteristics appear to be genetically determined and could not be explained by host-induced modification or virus mixtures. There was no correlation between host range and Gross-AKR or FMR serotype.

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