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J Virol. 1983 December; 48(3): 765-769

Leupeptin inhibits retrovirus infection in mouse fibroblasts.

K B Andersen

ABSTRACT

The protease inhibitor leupeptin was shown to inhibit retrovirus infection in mouse fibroblasts at a step shortly after internalization of the virus particles. The inhibited step most likely was the passage of virus particles through the lysosomes or other acid vesicles. Leupeptin was also shown to inhibit degradation of virus particles in the lysosomes. The results are discussed with respect to the involvement of proteases in the infectious route.

J Virol. 1983 December; 48(3): 765-769




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Copyright © 1983 by the American Society for Microbiology. All rights reserved.