This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Smiley, J R Articles by Halpern, M E Search for Related Content PubMed PubMed Citation Articles by Smiley, J R Articles by Halpern, M E

 Previous Article  |  Next Article 

J Virol. 1983 August; 47(2): 301-310

Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences.

ABSTRACT

We examined the ability of deleted versions of the herpes simplex virus type 1 thymidine kinase gene, present in biochemically transformed mouse cells, to be induced in trans to a higher level of expression by superinfecting herpes simplex virus immediate early gene products. The results demonstrate that sequences mapping between -200 and -80 and between -70 and -12 are required for induction. As these regions are largely coincident with the previously identified thymidine kinase gene promoter, the results suggest that herpes simplex virus immediate early gene products or their metabolic product activate thymidine kinase expression by acting at the promoter region to increase the rate of transcription.

This article has been cited by other articles:

• Homa, F L, Glorioso, J C, Levine, M (1988). A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene.. Genes Dev. 2: 40-53 [Abstract]  
• Coen, D., Weinheimer, S., McKnight, S. (1986). A genetic approach to promoter recognition during trans induction of viral gene expression. Science 234: 53-59 [Abstract]