This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Danos, O Articles by Howley, P M Search for Related Content PubMed PubMed Citation Articles by Danos, O Articles by Howley, P M

 Previous Article  |  Next Article 

J Virol. 1983 May; 46(2): 557-566

Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes.

ABSTRACT

The DNA sequences of the genomes of the bovine type 1 and human type 1a papillomaviruses were compared. The overall organization of both genomes is very similar. Three areas of maximal homology were found in the L1 and E1/E2 genes, and at the beginning of L2. The conservation of homologous amino acid sequences encoded in the open reading frames argues that these segments represent real genes or exons. Within these segments, however, only certain domains of the putative proteins are preferentially conserved. Two polypeptide chains show homologous arrangement of the cysteine residue clusters Cys-X-X-Cys, despite a lack of conservation of the rest of the amino acid sequence. A significant sequence divergence in a region where the three reading frames are open suggests that papillomavirus genomes have evolved not solely by accumulation of point mutations. Conserved sequences were also found in the noncoding region, and their possible involvement in regulation of viral gene expression is discussed.

This article has been cited by other articles:

• Thomas, D. L., Shin, S., Jiang, B. H., Vogel, H., Ross, M. A., Kaplitt, M., Shenk, T. E., Javier, R. T. (1999). Early Region 1 Transforming Functions Are Dispensable for Mammary Tumorigenesis by Human Adenovirus Type 9. J. Virol. 73: 3071-3079 [Abstract] [Full Text]  
• Schlegel, R, Wade-Glass, M, Rabson, M., Yang, Y. (1986). The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide. Science 233: 464-467 [Abstract]