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J Virol. 1983 April; 46(1): 270-274
Copyright © 1983, American Society for Microbiology. All Rights Reserved.

Effects of Tunicamycin on Rotavirus Morphogenesis and Infectivity

Betty L. Petrie^1,, Mary K. Estes^1,2 and David Y. Graham^1,2,3

¹ Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77030
² Department of Medicine, Baylor College of Medicine, Houston, Texas 77030
³ Veterans Administration Medical Center, Houston, Texas 77030

ABSTRACT

The functions of the two rotavirus glycoproteins were investigated by using tunicamycin and a variant of SA11 rotavirus having nonglycosylated VP7. Results showed that glycosylation of VP7 is not required for normal viral morphogenesis and infectivity and suggested that the nonstructural glycoprotein is involved in assembly of the outer capsid.

Previous publications written under the name Betty C. Altenburg.

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