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J Virol. 1983 April; 46(1): 131-136
Copyright © 1983, American Society for Microbiology. All Rights Reserved.

Human Adenovirus Type 2 but Not Adenovirus Type 12 Is Mutagenic at the Hypoxanthine Phosphoribosyltransferase Locus of Cloned Rat Liver Epithelial Cells

Christos Paraskeva, Carl Roberts, Paul Biggs and Phillip H. Gallimore

¹ Department of Cancer Studies, Cancer Research Campaign Laboratories, University of Birmingham, The Medical School, Birmingham B15 2TJ, England

ABSTRACT

Using resistance to the base analog 8-azaguanine as a genetic marker, we showed that adenovirus type 2, but not adenovirus type 12, is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned diploid rat liver epithelial cells. Adenovirus type 2 increased the frequency of 8-azaguanine-resistant colonies by up to ninefold over the spontaneous frequency, depending on expression time and virus dose.

Present address: Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London WC2A 3PX, England.

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