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J Virol. 1983 January; 45(1): 104-113

Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.

I S Chen, K C Wilhelmsen and H M Temin

ABSTRACT

The cellular homolog of the onc sequences in the avian retrovirus reticuloendotheliosis virus strain T (v-rel) was studied by molecular cloning and nucleic acid hybridization. In contrast to v-rel sequences, which are 1.4 kilobase pairs long, the cellular homolog, c-rel, from line 15B chickens is at least 25 kilobase pairs long, with multiple apparent introns. A 4.0-kilobase polyadenylic acid-containing RNA transcript is the primary species of c-rel RNA present in uninfected chicken cells. Sequences at the 3' end of this c-rel RNA are not present in v-rel.

J Virol. 1983 January; 45(1): 104-113




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