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J Virol. 1982 December; 44(3): 852-863

Novel forms of woodchuck hepatitis virus DNA isolated from chronically infected woodchuck liver nuclei.

ABSTRACT

We cloned several unique forms of woodchuck hepatitis virus, a DNA virus closely related to hepatitis B virus, from a chronically infected woodchuck liver. Each of the three clones contained more than two genome equivalents of viral sequences with extensive rearrangements and no detectable cellular sequences. From the frequency by which they were isolated from a library of recombinant clones, we estimate that they are present in approximately one copy per cell. Of a total of 11 sites at which rearrangements were mapped in the clones, 10 occurred between segments of opposite polarity, and 1 occurred between segments of the same polarity. The possible significance of these findings to the persistence of virus production in infected cells is discussed.

This article has been cited by other articles:

• Seeger, C., Mason, W. S. (2000). Hepatitis B Virus Biology. Microbiol. Mol. Biol. Rev. 64: 51-68 [Abstract] [Full Text]  
• Wang, H.-P., Zhang, L., Dandri, M., Rogler, C. E. (1998). Antisense Downregulation of N-myc1 in Woodchuck Hepatoma Cells Reverses the Malignant Phenotype. J. Virol. 72: 2192-2198 [Abstract] [Full Text]