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J Virol. 1982 November; 44(2): 755-758
Copyright © 1982, American Society for Microbiology. All Rights Reserved.

Caprine Arthritis-Encephalitis Virus Is Distinct from Visna and Progressive Pneumonia Viruses as Measured by Genome Sequence Homology

¹ Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164
² U.S. Department of Agriculture, Science and Education Administration, Animal Disease Research Unit, Washington State University, Pullman, Washington 99164

ABSTRACT

Competitive inhibition of hybridization between ¹²⁵I-labeled caprine arthritis-encephalitis viral RNA and homologous cDNA by heterologous viral RNA shows that the caprine retrovirus shares <20% genome sequence homology with visna and progressive pneumonia viruses. These viruses, however, are indistinguishable in immunodiffusion reactions involving the major structural protein (p28).