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J Virol. 1982 July; 43(1): 328-331

Isolation and characterization of simian virus 40 early region deletion mutants.

L M Sompayrac and K J Danna

ABSTRACT

We constructed a tsB4/dl884 double-mutant helper virus and used it to isolate two simian virus 40 early region deletion mutants that lack about half of the DNA sequences normally used to encode the large tumor antigen (T). Both mutants make a normal-sized small t antigen, but neither mutant can replicate its DNA in the absence of a T+ helper.

J Virol. 1982 July; 43(1): 328-331






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Copyright © 1982 by the American Society for Microbiology. All rights reserved.