JVI Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Levy, J A
Right arrow Articles by Kane, J P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levy, J A
Right arrow Articles by Kane, J P

 Previous Article  |  Next Article 

J Virol. 1982 May; 42(2): 365-371

Transfer of mouse anti-xenotropic virus neutralizing factor to human lipoproteins.

J A Levy, J Dimpfl, D Hardman and J P Kane

ABSTRACT

We examined the migratory properties of the mouse serum protein responsible for specific neutralization of the endogenous mouse xenotropic type C virus and demonstrated that this neutralizing factor can be transferred from mouse lipoproteins to human and to nonreactive mouse lipoproteins. After acceptance of this activity by these lipoproteins, it could be back-transferred to human and to mouse lipoproteins. This result was compatible with equilibrium binding of the responsible proteins by several classes of lipoproteins. The best expression of the transferred activity occurred with human chylomicrons. Small quantities of neutralizing factor which exist in free dispersion in serum were also detected by mixing the p greater than 1.21 g/ml density fraction of mouse serum with human chylomicrons; antiviral activity was subsequently found associated with the human lipoproteins. This result reflects the potentiation of antiviral activity of the protein in a lipoprotein environment. These observations offer a useful approach for the eventual purification and characterization of the neutralizing factor.

J Virol. 1982 May; 42(2): 365-371




This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1982 by the American Society for Microbiology. All rights reserved.