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J Virol. 1969 October; 4(4): 480-489
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Replication of Canine Herpesvirus

II. Virus Development and Release in Infected Dog Kidney Cells

Departments of Pathology, Microbiology, and Laboratory Animal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

ABSTRACT

The studies reported in this paper demonstrate that, although canine herpesvirus differs from other herpesviruses in that it is characterized by a restricted host range, the pattern of virus development in the permissive host closely resembles that previously described for herpes simplex virus. These experiments also reveal the formation in the infected dog kidney cells of a system of tubules and channels in which virions accumulate. It is suggested that these membrane-bound structures serve to protect enveloped virus from being uncoated in the cytoplasm and function in virus release from the infected cells.

This article has been cited by other articles:

• Aurelian, L., Strandberg, J. D., Melendez, L. V., Johnson, L. A. (1971). Herpesvirus Type 2 Isolated from Cervical Tumor Cells Grown in Tissue Culture. Science 174: 704-707 [Abstract]