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J Virol. 1969 July; 4(1): 7-11
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Influence of the Rate of Cell Growth and Cell Density on Interferon Action in Chick Embryo Cells ¹

T. G. Rossman² and J. Vilek

Department of Microbiology, New York University Medical Center, New York, New York 10016

ABSTRACT

Chick embryo cells became more sensitive to the action of interferon the longer they remained in culture. This phenomenon was found even before confluency had been reached. The relative insensitivity of newly seeded cells was not due to a loss of receptors. Cells synthesizing deoxyribonucleic acid (DNA) at a high rate were less sensitive to interferon action than cells synthesizing DNA at a low rate, but the inhibition of DNA synthesis had no effect on interferon action. An increase in the number of cells used for seeding resulted in an earlier appearance of increased sensitivity to interferon action. These results are discussed in relation to the induction process in animal cells.

² Present address: Department of Pathology, New York University Medical Center, New York, N.Y.

¹ This work was taken in part from a dissertation by T. G. Rossman submitted to the faculty of New York University in partial fulfillment of the requirements for the Ph.D. degree.

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