This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Para, M F Articles by Spear, P G Search for Related Content PubMed PubMed Citation Articles by Para, M F Articles by Spear, P G

 Previous Article  |  Next Article 

J Virol. 1980 May; 34(2): 512-520

Immunoglobulin G(Fc)-binding receptors on virions of herpes simplex virus type 1 and transfer of these receptors to the cell surface by infection.

ABSTRACT

We have found that virions of herpes simplex virus type 1 have surface receptors capable of binding to the Fc region of immunoglobulin G and have also shown that the previously identified Fc-binding glycoprotein (designated gE) is present in extracts prepared from purified virions. The technique of affinity chromatography was used to detect gE. Two approaches were used to demonstrate the presence of Fc-binding receptors on intact virions. First, it was shown that [125I]-immunoglobulin G, but not [125I]F(ab')2 fragments, cosedimented with virions in sucrose gradients and, second, electron microscopy was done to show that soluble peroxidase-antiperoxidase complexes bound to virions. The use of peroxidase-antiperoxidase complexes also permitted us to demonstrate that Fc-binding receptors from input (parental) virions become incorporated into the surface membranes of infected cells. This occurs presumably as a consequence of fusion between the virion envelope and cell surface membrane.

This article has been cited by other articles:

• Atalay, R., Zimmermann, A., Wagner, M., Borst, E., Benz, C., Messerle, M., Hengel, H. (2002). Identification and Expression of Human Cytomegalovirus Transcription Units Coding for Two Distinct Fc{gamma} Receptor Homologs. J. Virol. 76: 8596-8608 [Abstract] [Full Text]  
• Chapman, T. L., You, I., Joseph, I. M., Bjorkman, P. J., Morrison, S. L., Raghavan, M. (1999). Characterization of the Interaction between the Herpes Simplex Virus Type I Fc Receptor and Immunoglobulin G. J. Biol. Chem. 274: 6911-6919 [Abstract] [Full Text]  
• Nagashunmugam, T., Lubinski, J., Wang, L., Goldstein, L. T., Weeks, B. S., Sundaresan, P., Kang, E. H., Dubin, G., Friedman, H. M. (1998). In Vivo Immune Evasion Mediated by the Herpes Simplex Virus Type 1 Immunoglobulin G Fc Receptor. J. Virol. 72: 5351-5359 [Abstract] [Full Text]