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J Virol. 1980 January; 33(1): 539-542

Phosphonoacetic Acid Inhibition of Frog Virus 3 Replication

R. M. Elliott, A. Bateson and D. C. Kelly

¹ Unit of Invertebrate Virology, Natural Environment Research Council, and Department of Forestry, University of Oxford, Oxford, OX1 3UB, United Kingdom

ABSTRACT

Phosphonoacetic acid at concentrations above 200 µg/ml inhibited the replication of frog virus 3 in BHK cells. The inhibition of viral DNA replication observed in these cells was reversible and correlated with the inhibition of the virus-induced DNA polymerase activity in an in vitro assay. The synthesis of frog virus 3-induced late or polypeptides was also inhibited by phosphonoacetic acid, although the early ( and ß) polypeptides were unaffected.

Present address: Department of Microbiology, Mount Sinai School of Medicine, City University of New York, New York, NY 10029.