This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chesebro, B Articles by Nishio, J Search for Related Content PubMed PubMed Citation Articles by Chesebro, B Articles by Nishio, J

Persistence of infectious Friend virus in spleens of mice after spontaneous recovery from virus-induced erythroleukemia.

ABSTRACT

Persistent infectious virus was detected in the majority of spleens of (C57BL/10 X A.BY)F1 mice after spontaneous recovery from Friend virus-induced erythroleukeima. The Friend murine leukemia helper virus (F-MuLV) was detected in titers up to 3 X 10(5) PFU/g of spleen. The defective spleen focus-forming virus (SFFV) was present in much lower titers and could be detected in cell-free spleen homogenates only after amplification of virus titer by growth of virus in vitro on SC1 cells. The incidence of cells producing F-MuLV alone in spleens after recovery from leukemia was 0.003 to 0.3%, and the incidence of cells producing both F-MuLV and SFFV was less than 0.0001 to 0.01%. In most recovered mouse spleens there appeared to be a selective reduction of SFFV relative to F-MuLV.

This article has been cited by other articles:

• Robertson, S. J., Messer, R. J., Carmody, A. B., Mittler, R. S., Burlak, C., Hasenkrug, K. J. (2008). CD137 Costimulation of CD8+ T Cells Confers Resistance to Suppression by Virus-Induced Regulatory T Cells. J. Immunol. 180: 5267-5274 [Abstract] [Full Text]  
• Zelinskyy, G., Robertson, S. J., Schimmer, S., Messer, R. J., Hasenkrug, K. J., Dittmer, U. (2005). CD8+ T-Cell Dysfunction due to Cytolytic Granule Deficiency in Persistent Friend Retrovirus Infection. J. Virol. 79: 10619-10626 [Abstract] [Full Text]  
• Iwashiro, M., Peterson, K., Messer, R. J., Stromnes, I. M., Hasenkrug, K. J. (2001). CD4+ T Cells and Gamma Interferon in the Long-Term Control of Persistent Friend Retrovirus Infection. J. Virol. 75: 52-60 [Abstract] [Full Text]  
• Dittmer, U., Brooks, D. M., Hasenkrug, K. J. (1999). Protection against Establishment of Retroviral Persistence by Vaccination with a Live Attenuated Virus. J. Virol. 73: 3753-3757 [Abstract] [Full Text]  
• Dittmer, U., Brooks, D. M., Hasenkrug, K. J. (1998). Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms. J. Virol. 72: 6554-6558 [Abstract] [Full Text]  
• Hasenkrug, K. J., Brooks, D. M., Dittmer, U. (1998). Critical Role for CD4+ T Cells in Controlling Retrovirus Replication and Spread in Persistently Infected Mice. J. Virol. 72: 6559-6564 [Abstract] [Full Text]  
• Hasenkrug, K. J., Chesebro, B. (1997). Immunity to retroviral infection: The Friend virus model. Proc. Natl. Acad. Sci. USA 94: 7811-7816 [Abstract] [Full Text]  
• Earl, P., Moss, B, Morrison, R., Wehrly, K, Nishio, J, Chesebro, B (1986). T-lymphocyte priming and protection against Friend leukemia by vaccinia-retrovirus env gene recombinant. Science 234: 728-731 [Abstract]  
• Iwashiro, M., Messer, R. J., Peterson, K. E., Stromnes, I. M., Sugie, T., Hasenkrug, K. J. (2001). Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc. Natl. Acad. Sci. USA 98: 9226-9230 [Abstract] [Full Text]