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J Virol. 1979 April; 30(1): 404-409

Neoplastic transformation of cultured Syrian hamster embryo cells by DNA of herpes simplex virus type 2.

R J Jariwalla, L Aurelian and P O Ts'o

ABSTRACT

Syrian hamster embryo cells were transformed to a neoplastic phenotype after exposure to herpes simplex virus type 2 (S-1) DNA at concentrations (less than or equal to 0.01 microgram per 60-mm dish) at which infectivity was no longer demonstrable. Transformed cells manifested in vitro phenotypic properties characteristic of the neoplastic state, expressed herpes simplex virus-specific antigens, and induced invasive tumors in vivo. Transfection and transformation of Syrian hamster embryo cells with herpes simplex virus type 2 DNA or its fragments is a suitable system for investigating the structure and function of herpes simplex virus-transforming gene(s).

J Virol. 1979 April; 30(1): 404-409






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