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J Virol. 1969 February; 3(2): 176-180
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Physical and Chemical Properties of the Transmissible Mink Encephalopathy Agent

Department of Veterinary Science, College of Agricultural and Life Sciences, The University of Wisconsin, Madison, Wisconsin 53706

ABSTRACT

The size of the transmissible mink encephalopathy (TME) agent is estimated to be less than 50 nm on the basis of its passage through membrane filters. The agent is sensitive to ether, relatively resistant to 10% Formalin, resistant to ultraviolet irradiation, and susceptible to proteolytic digestion with Pronase. Attempts to extract an infectious nucleic acid fraction with hot phenol were unsuccessful. The results of these studies indicate that the TME agent has biochemical properties which are similar to those described for the transmissible agent of scrapie.

¹ Present address: National Institute of Neurological Diseases and Blindness, Building 8, Room 100, Bethesda, Md. 20014.

This article has been cited by other articles:

• Eckroade, R. J., Rhein, G. M. Z., Marsh, R. F., Hanson, R. P. (1970). Transmissible Mink Encephalopathy: Experimental Transmission to the Squirrel Monkey. Science 169: 1088-1090 [Abstract]