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J Virol. 1969 February; 3(2): 146-149
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Reversion in Polyoma-transformed Cells: Retransformation, Induced Antigens and Tumorigenicity

International Laboratory of Genetics and Biophysics, Naples, Italy
Institute of Virology, University of Glasgow, Glasgow, Scotland

ABSTRACT

We studied the properties of two morphologically reverted cell clones isolated as chromosomal segregants from a "hybrid" clone of BHK 21/13 hamster fibroblasts, transformed with polyoma virus. Both clones were less tumorigenic than control transformed cells. They contained no detectable polyoma-specific complement-fixing antigen. Induced transplantation antigen also appeared to be lost or reduced. Both clones could be retransformed with polyoma virus, suggesting that their reversion is due to the loss of viral genes from the transformed cell.

¹ Present address: Imperial Cancer Research Fund, Lincoln's Inn Fields, London, England.