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J Virol. 1978 April; 26(1): 110-114

Persistent infection of BHK-21 cells with pneumonia virus of mice.

S E Gallaspy, J E Coward and C Howe

ABSTRACT

Trypsinization of BHK-21 cells 72 h after primary infection with pneumonia virus of mice yielded clones of persistently infected cells which specifically adsorbed murine erythrocytes. We describe one clone of cells, the progeny of which, after more than 100 passages, still bore viral antigen demonstrable by immunofluorescence and immune electron microscopy, but produced little or no detectable infectious virus.

J Virol. 1978 April; 26(1): 110-114






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Copyright © 1978 by the American Society for Microbiology. All rights reserved.