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J Virol. 1977 August; 23(2): 443-447

Biochemical and immunological characterization of the major envelope glycoprotein of bovine leukemia virus.

S G Devare and J R Stephenson

ABSTRACT

The major envelope glycoprotein of bovine leukemia virus was isolated by lectin-bound Sepharose and DEAE-cellulose column chromatography. This protein was shown to have a molecular weight of about 41,000 and to lack detectable immunological cross-reactivity with glycoproteins of other oncornaviruses. Sera obtained from 100% of cattle examined with clinically diagnosed lymphosarcoma contained high-titered antibody to 125I-labeled bovine leukemia virus glycoprotein, whereas sera from animals in a disease-free herd were antibody negative.

J Virol. 1977 August; 23(2): 443-447






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