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J Virol. 1968 September; 2(9): 901-904
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Inactivating and Mutagenic Effects of 1-Methyl-3-Nitro-1-Nitrosoguanidine on Intracellular Bacteriophage

Antonio Zampieri1, Joseph Greenberg2 and Guylyn Warren

Palo Alto Medical Research Foundation, Palo Alto, California 94301

ABSTRACT

1-Methyl-3-nitro-1-nitrosoguanidine (NG) was able to inactivate and mutate adsorbed but not free coliphage T2. Coliphage T4 was as sensitive to NG as T2. When treatment was delayed for 5 min or longer after adsorption of T2, the phage became increasingly refractory to NG inactivation.

FOOTNOTES

1 Present address: Universita di Milano, Istituto di Microbiologia, Milano, Italy.

2 Recipient of Public Health Service Research Development Award.

J Virol. 1968 September; 2(9): 901-904
Copyright © 1968 American Society for Microbiology. All Rights Reserved.





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